A Novel Candidate for Cancer Vaccines: The Potential and Limitations of the circRNA Platform
mRNA vaccines, together with the COVID-19 pandemic, rapidly transformed from a laboratory setting into a global public health tool; this success has opened the way for new development efforts directed at cancer immunotherapy, respiratory vaccines, and infectious...
RoboChem-Flex Platform: The Self-Managing Laboratory
Chemical experiments conducted in laboratories have become faster and more reproducible with the advancement of automation and robotic systems. Although self-driving laboratory (SDL) systems, in particular, have the potential to accelerate experimental processes, they...
Artificial Intelligence in Protein Design: Allosteric Biosensors Using Machine Learning
Protein allostery (the phenomenon in which a signal received by one region of a protein triggers a response in a distant functional region) constitutes the fundamental mechanism of real-time information processing and energy transfer at the cellular level. The vast...
Potential Threat: Bioterrorism
Deniz AkyüzA. , Elif DuymazE. Since the dawn of humanity, societies and nascent states have often found themselves in contention with neighboring states and primitive communities. In those early years, the most formidable and influential tools wielded as leverage were...
Structure-based Drug Design
Ece OdabaşıT. Elif AtayE During the development process of a drug, it is crucial to assess the potential interactions of new drugs with therapeutic targets1. The discovery cycle of a drug until its approval by the US Food and Drug Administration (FDA)...
The Next Generation Warrior Against Cancer: CAR-T Cells
Bensu Sıla Çelik T., Elif DuymazE. Chimeric antigen receptors (CARs) are synthetic receptors that function to reprogram immune cells, particularly T cells, to recognize and kill cells expressing specific antigens1. CAR-T cells are T cells engineered to combine T cell...
Model Organisms Review Series – II: Pichia Pastoris and Their Usage Areas
Gülşah AkçadağA., Elif AltayE. Pichia pastoris has been described as Zygosaccharomyces pastoris by Alexandre Guilliermond who is French mycologist in 19201. After, similar strains were isolated from oak trees by Herman Phaff and given the name P. pastoris 30-40 years...
Beyond the Atmosphere: Space and Human Health
Ayça DöngelT. , Elif DuymazE. Since Yuri Gagarin performed the first human spacewalk in19611, research in the fields of astrobiology2, gravity biology3, space biology4, and space medicine5 has discovered novel biological responses to the space environment. Such as the...
Components of Biosensors and Applications
Sarehan AkyüzT, Ebru KavaklıE. Monitoring of chemical and biological processes is of great importance in the field of medical and biological applications1. Dynamic and real-time monitoring of these processes involves complex steps, and innovations in this field...
Sanitarians in Our Bodies: Living Therapeutics
Elif AtayT., Elif DuymazE. Living therapeutics is the name of living organisms conceived to treat, prevent a disease, or maintain the current situation1. A living therapeutic can also be designed to produce and represent other therapeutics asin its original place2....