Structure-based Drug Design
Ece OdabaşıT. Elif AtayE During the development process of a drug, it is crucial to assess the potential interactions of new drugs with therapeutic targets1. The discovery cycle of a drug until its approval by the US Food and Drug Administration (FDA)...
The Next Generation Warrior Against Cancer: CAR-T Cells
Bensu Sıla Çelik T., Elif DuymazE. Chimeric antigen receptors (CARs) are synthetic receptors that function to reprogram immune cells, particularly T cells, to recognize and kill cells expressing specific antigens1. CAR-T cells are T cells engineered to combine T cell...
Model Organisms Review Series – II: Pichia Pastoris and Their Usage Areas
Gülşah AkçadağA., Elif AltayE. Pichia pastoris has been described as Zygosaccharomyces pastoris by Alexandre Guilliermond who is French mycologist in 19201. After, similar strains were isolated from oak trees by Herman Phaff and given the name P. pastoris 30-40 years...
Beyond the Atmosphere: Space and Human Health
Ayça DöngelT. , Elif DuymazE. Since Yuri Gagarin performed the first human spacewalk in19611, research in the fields of astrobiology2, gravity biology3, space biology4, and space medicine5 has discovered novel biological responses to the space environment. Such as the...
Components of Biosensors and Applications
Sarehan AkyüzT, Ebru KavaklıE. Monitoring of chemical and biological processes is of great importance in the field of medical and biological applications1. Dynamic and real-time monitoring of these processes involves complex steps, and innovations in this field...
Sanitarians in Our Bodies: Living Therapeutics
Elif AtayT., Elif DuymazE. Living therapeutics is the name of living organisms conceived to treat, prevent a disease, or maintain the current situation1. A living therapeutic can also be designed to produce and represent other therapeutics asin its original place2....
Bacterial Factories: Metabolic Engineering
Azra AlınayT., Nida Dereli ÇalışkanE. Metabolic engineering, initially introduced to the literature by Jay Bailey in 1991, is defined as the enhancement of cellular activities through the manipulation of enzymatic, transport, and regulatory functions of the cell using...
CRISPR/Cas9 Based Gene Therapy
Ece OdabaşıT., Gülnur UzunE. The gene, which is the basic unit of heredity in living things, structurally contains the untranslated region (UTR), enhancer or silencer, and promoter areas at the 5' and 3' ends, and coding exons and non-coding introns between them. Gene...
Synthetic Biology: Extraordinarily Advanced Systems
Zehra Nur KoyuncuT., Nida Dereli ÇalışkanE. With the advancement of technology, there has been a tremendous expansion of scientific knowledge. This flow of information has led to the emergence of interdisciplinary fields such as "Synthetic Biology (SB)”. This...
Life, Space, and Future: Astroecology
Esma TopaloğluT., Gülnur UzunE. A multidisciplinary approach has become the main feature of scientific research that points to benefit from the diversity of information of complex systems on or outside of Earth, like biodiversity, ecological systems, and galaxies1....