RNA-based Therapeutics and The Future of RNA Therapy
Dilan AğırbaşA., Ebru KavaklıE. RNA therapy is a type of treatment that regulates biological pathways with RNA molecules to remedy a particular disease1. Manipulating gene expression and producing therapeutic proteins are fundamental functions of RNA therapies....
Stem Cell Technologies: Regenerative Medicine and Clinical Applications
Eslem EkemenT., Nida Dereli ÇalışkanE., Ebru KavaklıR. Stem cells are a group of cells that have the properties of differentiation, proliferation, and continuous self-renewal and can enable the production, repair, and regeneration of many tissues1-3. At the same time,...
The Concept of Exosomes and Their Therapeutic Potential
Elif AtayT., Gülnur UzunE. Exosomes classified as a subtype of extracellular vesicle (EV) and formed by endosomal way1-3, ~ have 30-150 nanometers (nm) diameter3-10 and spherical shape based on their scanning electron microscope (SEM)4,11-14; in addition, their...
From Mechanics to Tissue: Artificial Organ Design
Şehnaz Melisa AcarA., Tuğçe BinenE., Esra AvcıT., Gülnur UzunE. Although medical science is constantly making attempts to treat diseases that have serious and high mortality rates or reduce the quality of life, organ failure is one of the leading causes of death...
Model Organism Series I: Zebrafish (Danio rerio) and Their Usage Areas
Övgüm ÇolakoğluA., Nida DereliE. Introduction Model organisms can be utilized to comprehend particular biological processes and gather data that can bring light to how other organisms function. Many fish models have been used in the scientific world. Each fish species...
Cell Imaging: A Micro to Macro Adventure
Bensu Sıla Çelik T., Elif Duymaz E. Derived from the ancient Greek words micros (small) and skopein (seeing/looking), the microscope was invented in 1600 as an optical system that aims to make invisible cells and tissues visible1,2. Robert Hooke's first observations...
Viruses and Genetic Diversity
Zehra Nur KoyuncuT., Ebru KavaklıE. Genetic variation is the fundamental mechanism of evolution and provides a basis for organisms to overcome environmental challenges1. When these factors are considered, genetic variations essential for all biological systems are...
Paleogenetics: From Ancient Genomes to Modern Humans
Turna DemirciT. , Elif DuymazE. Paleogenetics is a new branch of science which focuses on ancient DNA (aDNA), genetic materials obtained from archaeological remains1,2. The aDNA was first isolated in 1984 by Higuchi and colleagues from a 150-year-old tissue belonging...
Overview of Deep Learning and Genomics Uses
Elif DuymazA.. , Fatma DuranE. Machine learning (ML) is a subset of artificial intelligence (AI) that focuses on developing algorithms capable of instantiating different aspects of human intelligence1. Initially proposed by McCulloch and Pitts and inspired by the...
Next Generation Folding Architecture: De Novo Protein Design
Minel CengizT., Elif DuymazE. Proteins, one of the four groups of macromolecules necessary for the continuation of life, are initially linear polypeptide chains called primary structure and formed by the combination of amino acids in a certain order. Proteins perform...