Evolutionary Secret: Hominoid Tail Loss
The tail loss in human evolution is considered one of the most remarkable anatomical changes in the evolution process. Tail loss has led to people becoming bipedal and the formation of anthropomorph monkeys, but the genetic mechanism that initiated tail loss evolution...
Data Science Predicts: Cu-Catalyzed C–N Coupling Reactions
In recent years, advances in high-throughput experimentation (HTE) along with machine learning (ML) algorithms have revolutionized the process of identifying successful reactions in synthetic chemistry. ML algorithms, when combined with HTE, enable efficient...
Dynamic and Selective Engrams: Their Relationship to Memory Consolidation
A mounting body of evidence indicates the pivotal involvement of neurons activated during experiences in both the establishment and retrieval of memories. These neurons, termed engram cells, represent a foundational element in the process of memory encoding and...
Secrets Stealthily Navigating Nuclear Pores: HIV-1 Capsids
Recent groundbreaking research unveils how HIV-1, the virus accountable for AIDS, challenges conventional comprehension by circumventing cellular defenses to access the nucleus. The virus accomplishes this feat by infiltrating nuclear pore complexes (NPCs), typically...
Reveals DENV Antibodies via Machine Learning
Dengue virus, comprising four serotypes (DENV1-4), initiates an immune response upon infection, leading to the production of antibodies, the body's defense mechanism. These serotypes are distinguished by their immunodominant antigen protein E, which forms the virus's...
Structure-based Drug Design
Ece OdabaşıT. Elif AtayE During the development process of a drug, it is crucial to assess the potential interactions of new drugs with therapeutic targets1. The discovery cycle of a drug until its approval by the US Food and Drug Administration (FDA)...
Green Synthesis: Silver Nanoparticles for Therapeutic Applications
Noble metal nanoparticles (NPs), targeted for green synthesis, have garnered significant attention due to their distinct characteristics in comparison to the macroscopic phase. Among various potential applications, silver nanoparticles (AgNPs) have been extensively...
Biosensors in Liver Cancer: Revolution in Early Diagnosis
Alfa-fetoprotein (AFP), primarily produced by the fetal liver, is a glycoprotein; however, its elevated levels in adults are particularly associated with liver cancer. In this context, AFP plays an influential role as a biomarker for the diagnosis and monitoring of...
The Next Generation Warrior Against Cancer: CAR-T Cells
Bensu Sıla Çelik T., Elif DuymazE. Chimeric antigen receptors (CARs) are synthetic receptors that function to reprogram immune cells, particularly T cells, to recognize and kill cells expressing specific antigens1. CAR-T cells are T cells engineered to combine T cell...
Stem Cells: Patterned Human Heart Organoid
Pluripotent stem cell-derived organoids hold the capacity to emulate key aspects of organ development in vitro. By employing a self-organization-driven developmental induction strategy, the study focuses on creating human heart organoids that closely mimic in-utero...