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A Novel Therapeutic Approach for Peroxisomal Disorders: Repair of the PEX1 Gene Through Base Editing

A Novel Therapeutic Approach for Peroxisomal Disorders: Repair of the PEX1 Gene Through Base Editing

by Bioinfocodes | Jul 24, 2026 | Bioinfonews

Zellweger spectrum disorder (ZSD) is a genetic disorder caused by mutations in PEX genes, which are responsible for the formation of peroxisomes, organelles that play critical roles in cellular metabolism and signal transduction. The PEX1-p.G843D mutation, observed in...
A Novel Candidate for Cancer Vaccines: The Potential and Limitations of the circRNA Platform

A Novel Candidate for Cancer Vaccines: The Potential and Limitations of the circRNA Platform

by Bioinfocodes | Jul 17, 2026 | Bioinfonews, Bioinformatics

mRNA vaccines, together with the COVID-19 pandemic, rapidly transformed from a laboratory setting into a global public health tool; this success has opened the way for new development efforts directed at cancer immunotherapy, respiratory vaccines, and infectious...
Early Plague Outbreaks in Hunter-Gatherers: The Origin of Yersinia pestis Dates Back 5,700 Years

Early Plague Outbreaks in Hunter-Gatherers: The Origin of Yersinia pestis Dates Back 5,700 Years

by Bioinfocodes | Jul 10, 2026 | Bioinfonews

Plague is recognized as one of the most devastating infectious diseases in human history. However, the extent to which the early evolutionary forms of the bacterium Yersinia pestis, the causative agent of plague, were lethal has long been a subject of debate. Since...
Learning the DNA Language: The Developed dnaHNet Model for Genome Analysis

Learning the DNA Language: The Developed dnaHNet Model for Genome Analysis

by Bioinfocodes | Jun 30, 2026 | Bioinfonews

Foundation models (FMs) are artificial intelligence models trained on large-scale datasets and possessing generalized learning capabilities that can be used in various tasks. Decoding DNA syntax provides an indispensable infrastructure for processes such as disease...
Translation in Giant Viruses: Overcoming Genetic Mismatch Through Viral Factories

Translation in Giant Viruses: Overcoming Genetic Mismatch Through Viral Factories

by Bioinfocodes | Jun 23, 2026 | Bioinfonews

Translation is one of the most fundamental biological processes essential for the continuation of life, and viruses depend on the host cell’s translational machinery for replication. However, a significant genetic mismatch exists between giant viruses such as...
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