Next-Generation Human Organoids: Engineering Cellular Complexity For Disease Modelling And Drug Discovery
Human organoid technology has emerged as a powerful platform for studying human biology and disease in vitro. Organoids are self-organizing three-dimensional (3D) cellular structures derived from pluripotent stem cells (PSCs) or tissue-resident stem cells that...
AI-Driven Scientific Software Development: ERA Automates Iterative Software Optimization
Computational methods have become essential for scientific research, supporting applications ranging from genomics to disease forecasting. However, developing high-performing scientific software often requires repeated experimentation and optimization. Although large...
Neurobiology: Glial mitochondrial transfer rescues sensory neuron degeneration
Primary sensory neurons located in the dorsal root ganglia (DRG) possess long peripheral axons that can extend up to one meter, creating high bioenergetic demands that require continuous mitochondrial function. Because mitochondrial dysfunction contributes to axonal...
Single-Cell Technologies: The Billion Cell Project Establishes a Functional Atlas of Cellular Interactions
Understanding how individual cells interact to shape tissue function remains a central focus in multicellular biology and biotechnology. While recent advances in single-cell transcriptomics (the profiling of RNA expression in individual cells) and spatial profiling...
Non-Caffeine Bioactive Compounds: Coffee Intake Reduces Systemic Inflammation And Enhances Memory
Understanding the interactions between dietary habits, the gut microbiome (the community of microorganisms living in the digestive tract), and host physiology is a central focus in modern biomedical research. Dietary components can alter microbial populations and...
The Digital Twin Revolution in Biotechnology: Personalized Drug Analysis with Ex Vivo Lung Models
Ex vivo lung perfusion (EVLP) presents a critical biotechnological platform in the evaluation of donated organs before transplantation and in the examination of biological processes. This technology enables the production of comprehensive data sets consisting of...
A Novel Therapeutic Approach for Peroxisomal Disorders: Repair of the PEX1 Gene Through Base Editing
Zellweger spectrum disorder (ZSD) is a genetic disorder caused by mutations in PEX genes, which are responsible for the formation of peroxisomes, organelles that play critical roles in cellular metabolism and signal transduction. The PEX1-p.G843D mutation, observed in...
A Novel Candidate for Cancer Vaccines: The Potential and Limitations of the circRNA Platform
mRNA vaccines, together with the COVID-19 pandemic, rapidly transformed from a laboratory setting into a global public health tool; this success has opened the way for new development efforts directed at cancer immunotherapy, respiratory vaccines, and infectious...
Early Plague Outbreaks in Hunter-Gatherers: The Origin of Yersinia pestis Dates Back 5,700 Years
Plague is recognized as one of the most devastating infectious diseases in human history. However, the extent to which the early evolutionary forms of the bacterium Yersinia pestis, the causative agent of plague, were lethal has long been a subject of debate. Since...
Learning the DNA Language: The Developed dnaHNet Model for Genome Analysis
Foundation models (FMs) are artificial intelligence models trained on large-scale datasets and possessing generalized learning capabilities that can be used in various tasks. Decoding DNA syntax provides an indispensable infrastructure for processes such as disease...