Early Plague Outbreaks in Hunter-Gatherers: The Origin of Yersinia pestis Dates Back 5,700 Years
Plague is recognized as one of the most devastating infectious diseases in human history. However, the extent to which the early evolutionary forms of the bacterium Yersinia pestis, the causative agent of plague, were lethal has long been a subject of debate. Since...
Learning the DNA Language: The Developed dnaHNet Model for Genome Analysis
Foundation models (FMs) are artificial intelligence models trained on large-scale datasets and possessing generalized learning capabilities that can be used in various tasks. Decoding DNA syntax provides an indispensable infrastructure for processes such as disease...
Translation in Giant Viruses: Overcoming Genetic Mismatch Through Viral Factories
Translation is one of the most fundamental biological processes essential for the continuation of life, and viruses depend on the host cell’s translational machinery for replication. However, a significant genetic mismatch exists between giant viruses such as...
Overcoming The Limits Of Genome: Horizontal Gene Transfer Between Human Cells
Under normal circumstances, the mammalian genome is protected within the safe boundaries of the interphase nucleus, and the stability of cellular functions is maintained by this spatial separation. However, genomic instability caused by factors such as cell division...
Structural Atlas of Viral Proteins: Development of the Viral AlphaFold Database
Viruses rank among the most abundant biological entities in the biosphere and display remarkable genetic diversity. Their ability to infect bacteria, archaea, and eukaryotes has established viral systems as a significant area of biological research. Despite this, the...
From Language Models to Biological Reasoning: Protein Function Prediction with BioReason-Pro
Proteins, as the fundamental functional units of cellular life, govern a wide range of biochemical processes, from metabolism to intracellular signaling. Advances in high-throughput sequencing technologies have led to the accumulation of over 250 million protein...
RoboChem-Flex Platform: The Self-Managing Laboratory
Chemical experiments conducted in laboratories have become faster and more reproducible with the advancement of automation and robotic systems. Although self-driving laboratory (SDL) systems, in particular, have the potential to accelerate experimental processes, they...
Recoding the Immune System: In Vivo CAR-T Therapy in Multiple Myeloma
Multiple myeloma is a malignancy characterized by the uncontrolled proliferation of plasma cells in the bone marrow and accounts for approximately 10% of all hematological cancers. Despite advances in treatment modalities such as proteasome inhibitors,...
Artificial Intelligence in Protein Design: Allosteric Biosensors Using Machine Learning
Protein allostery (the phenomenon in which a signal received by one region of a protein triggers a response in a distant functional region) constitutes the fundamental mechanism of real-time information processing and energy transfer at the cellular level. The vast...
RNA Folding: Real-Time Monitoring at the Single-Molecule Level
The three-dimensional structure of RNA (ribonucleic acid) molecules is of fundamentally important for cellular processes. Many biological functions, including ribosome formation (the cell’s protein factory), depend on the correct folding of RNA. However, RNA molecules...