Prediction of Mutagen Pathogenicity in the Human Genome by Using Online Tools
Damla PehlivanT., Maryam MounadR. Introduction Changes that occur in an organism's genome are called genetic mutations. Mistakes can happen during the replication of DNA, which might lead to mutations in organisms. Mutations can also be caused by UV light and exposure...
Proton Tunnelling in DNA: Quantum Systems Approach
Fatma ÇiçekY., Sema YöşiliE. The genetic stability of DNA is one of the most important topics in molecular biology. Proton transfer along the hydrogen bonds of DNA can lead to tautomerization and thus, point mutations that pose a threat to the genetic stability of...
Cheminformatics and Machine Learning in Drug Discovery
Sema YöşiliT., Mehmet ÇalısekiE. Damla PehlivanR. Introduction Chemistry is one of the richest disciplines in terms of information and has been for many years. Most information in chemistry is concerned with the two- and three-dimensional (2D and 3D) structures of...
Overview of CRISPR-Cas Editing Tools for Gene Therapy
Ece GüvenA., Elif DuymazE., Sema YöşiliR. Introduction After the discovery of clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) system in bacterial adaptive immunity against foreign genetic elements like viruses, they have been...
Multiplex Activation in Mammalian Genome: split-intein CRISPR/Cas12a
Author: İrem Sinem Acınan, Editor: Ece Güven, Redactor: Ece Odabaşı Generating synthetic transcription factors for targeting different loci became much easier via clustered regularly interspersed palindromic repeats (CRISPR) systems. As known, CRISPR systems provided...
Less Time More Work: ET-seq and DART
Author: İrem Eroğlu, Editor: Ece Güven, Redactor: Ayşe Naz Cerit Observing the effects of genetic mutations on the phenotype is the first way to understand gene function in microorganisms. This classical path requires manipulation of the living in isolation, which is...
ILC3s: New Potential Target for Neuroinflammatory Diseases
Author: Ece Güven, Editor: Elif Duymaz , Redactor: Sema Yöşili It is known that pro-inflammatory autoreactive T cells in the central nervous system (CNS) are responsible for autoimmune diseases with neuroinflammation, such as multiple sclerosis (MS) and also for...
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