Overview of CRISPR-Cas Editing Tools for Gene Therapy
Ece GüvenA., Elif DuymazE., Sema YöşiliR. Introduction After the discovery of clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) system in bacterial adaptive immunity against foreign genetic elements like viruses, they have been...
Multiplex Activation in Mammalian Genome: split-intein CRISPR/Cas12a
Author: İrem Sinem Acınan, Editor: Ece Güven, Redactor: Ece Odabaşı Generating synthetic transcription factors for targeting different loci became much easier via clustered regularly interspersed palindromic repeats (CRISPR) systems. As known, CRISPR systems provided...
Less Time More Work: ET-seq and DART
Author: İrem Eroğlu, Editor: Ece Güven, Redactor: Ayşe Naz Cerit Observing the effects of genetic mutations on the phenotype is the first way to understand gene function in microorganisms. This classical path requires manipulation of the living in isolation, which is...
ILC3s: New Potential Target for Neuroinflammatory Diseases
Author: Ece Güven, Editor: Elif Duymaz , Redactor: Sema Yöşili It is known that pro-inflammatory autoreactive T cells in the central nervous system (CNS) are responsible for autoimmune diseases with neuroinflammation, such as multiple sclerosis (MS) and also for...
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