Irritability in Childhood: Neuro-Structural Correlations
Irritability is a transdiagnostic symptom that often leads to a child's referral to mental health services and is associated with neuro-structural abnormalities. Disruptions in neural circuits are caused by differences in sensory processing, brain regions associated...
Genetic Variation in Alzheimer’s Disease: Effect on Disease Progression
Alzheimer's disease is defined as a progressive neurodegenerative disorder that affects millions of individuals worldwide. This disease, which particularly emerges in older age, is characterized by memory loss, cognitive decline, and the loss of daily living skills....
Sphingolipids: Unlocking Cancer’s Immune Evasion
Cancer cells rely on specific lipid pathways, such as sphingolipids, for growth and proliferation, leading to an upregulation of lipid synthesis. While it is established that an excess of lipids can promote metastasis and immune evasion in murine models, the specific...
Schwann Cells: The Hidden Force Behind Neurons
As the fundamental building blocks of the nervous system, neurons have long been at the center of neurobiological research, forming intricate networks within living organisms and displaying key properties such as excitability. Excitability is defined as the ability to...
Proteomic Age Clock: A New Way to Understand Aging
Aging has a significant impact on chronic diseases and mortality rates. As people age, the incidence of these diseases increases; however, chronological age may not fully reflect individuals' biological aging processes. Omic data allow for a more accurate prediction...
Reappraisal and Shame Management: Comparing Autism and Typical Individuals
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition marked by repetitive behaviors, restricted interests, emotional dysregulation, and significant challenges in social interactions. The social impairments characteristic of ASD often lead to...
The Power of Genetic Silencing: CRISPRoff vs ZFcharm
Prion disease derives from the accumulation of the misfolded, toxic forms of the proteins called PrnP in the neurons, which might conclude with the death of neurons. Along with the fact that it is a fatal and rare degenerative disorder, there is no treatment yet. It...
Epithelial Exosomes: New Frontiers in Fibrosis Diagnosis
Fibrosis involves the abnormal accumulation of extracellular matrix proteins and disrupted tissue repair, resulting in permanent scar tissue due to injury. Exosomes, tiny vesicles containing signaling molecules like mRNAs and proteins, are secreted by epithelial cells...
Potential Threat: Bioterrorism
Deniz AkyüzA. , Elif DuymazE. Since the dawn of humanity, societies and nascent states have often found themselves in contention with neighboring states and primitive communities. In those early years, the most formidable and influential tools wielded as leverage were...
Beyond CRISPR: Bacterial Genome Editing with Reprogrammable RNA
The rearrangement and diversification of the genome have endowed numerous enzymes through evolution. The emergence of new genes and their functional diversification, immune development, virus dissemination, and mobile genetic elements (MGEs) occur during this process....