Epithelial Exosomes: New Frontiers in Fibrosis Diagnosis
Fibrosis involves the abnormal accumulation of extracellular matrix proteins and disrupted tissue repair, resulting in permanent scar tissue due to injury. Exosomes, tiny vesicles containing signaling molecules like mRNAs and proteins, are secreted by epithelial cells...
Potential Threat: Bioterrorism
Deniz AkyüzA. , Elif DuymazE. Since the dawn of humanity, societies and nascent states have often found themselves in contention with neighboring states and primitive communities. In those early years, the most formidable and influential tools wielded as leverage were...
Beyond CRISPR: Bacterial Genome Editing with Reprogrammable RNA
The rearrangement and diversification of the genome have endowed numerous enzymes through evolution. The emergence of new genes and their functional diversification, immune development, virus dissemination, and mobile genetic elements (MGEs) occur during this process....
Glioblastoma: Tumor Segregation and Immune Suppression via snRNA-seq
In the realm of glioblastoma (GBM) treatment, a malignant brain tumor with direct outcomes, conventional single cell technologies (TME) have played a pivotal role in discerning various cell types. However, they fall short in providing the precise tissue-level details...
Evolutionary Secret: Hominoid Tail Loss
The tail loss in human evolution is considered one of the most remarkable anatomical changes in the evolution process. Tail loss has led to people becoming bipedal and the formation of anthropomorph monkeys, but the genetic mechanism that initiated tail loss evolution...
Data Science Predicts: Cu-Catalyzed C–N Coupling Reactions
In recent years, advances in high-throughput experimentation (HTE) along with machine learning (ML) algorithms have revolutionized the process of identifying successful reactions in synthetic chemistry. ML algorithms, when combined with HTE, enable efficient...
Dynamic and Selective Engrams: Their Relationship to Memory Consolidation
A mounting body of evidence indicates the pivotal involvement of neurons activated during experiences in both the establishment and retrieval of memories. These neurons, termed engram cells, represent a foundational element in the process of memory encoding and...
Secrets Stealthily Navigating Nuclear Pores: HIV-1 Capsids
Recent groundbreaking research unveils how HIV-1, the virus accountable for AIDS, challenges conventional comprehension by circumventing cellular defenses to access the nucleus. The virus accomplishes this feat by infiltrating nuclear pore complexes (NPCs), typically...
Reveals DENV Antibodies via Machine Learning
Dengue virus, comprising four serotypes (DENV1-4), initiates an immune response upon infection, leading to the production of antibodies, the body's defense mechanism. These serotypes are distinguished by their immunodominant antigen protein E, which forms the virus's...
Structure-based Drug Design
Ece OdabaşıT. Elif AtayE During the development process of a drug, it is crucial to assess the potential interactions of new drugs with therapeutic targets1. The discovery cycle of a drug until its approval by the US Food and Drug Administration (FDA)...