Secrets Stealthily Navigating Nuclear Pores: HIV-1 Capsids
Recent groundbreaking research unveils how HIV-1, the virus accountable for AIDS, challenges conventional comprehension by circumventing cellular defenses to access the nucleus. The virus accomplishes this feat by infiltrating nuclear pore complexes (NPCs), typically...
Reveals DENV Antibodies via Machine Learning
Dengue virus, comprising four serotypes (DENV1-4), initiates an immune response upon infection, leading to the production of antibodies, the body's defense mechanism. These serotypes are distinguished by their immunodominant antigen protein E, which forms the virus's...
Structure-based Drug Design
Ece OdabaşıT. Elif AtayE During the development process of a drug, it is crucial to assess the potential interactions of new drugs with therapeutic targets1. The discovery cycle of a drug until its approval by the US Food and Drug Administration (FDA)...
Green Synthesis: Silver Nanoparticles for Therapeutic Applications
Noble metal nanoparticles (NPs), targeted for green synthesis, have garnered significant attention due to their distinct characteristics in comparison to the macroscopic phase. Among various potential applications, silver nanoparticles (AgNPs) have been extensively...
Biosensors in Liver Cancer: Revolution in Early Diagnosis
Alfa-fetoprotein (AFP), primarily produced by the fetal liver, is a glycoprotein; however, its elevated levels in adults are particularly associated with liver cancer. In this context, AFP plays an influential role as a biomarker for the diagnosis and monitoring of...
The Next Generation Warrior Against Cancer: CAR-T Cells
Bensu Sıla Çelik T., Elif DuymazE. Chimeric antigen receptors (CARs) are synthetic receptors that function to reprogram immune cells, particularly T cells, to recognize and kill cells expressing specific antigens1. CAR-T cells are T cells engineered to combine T cell...
Stem Cells: Patterned Human Heart Organoid
Pluripotent stem cell-derived organoids hold the capacity to emulate key aspects of organ development in vitro. By employing a self-organization-driven developmental induction strategy, the study focuses on creating human heart organoids that closely mimic in-utero...
Model Organisms Review Series – II: Pichia Pastoris and Their Usage Areas
Gülşah AkçadağA., Elif AltayE. Pichia pastoris has been described as Zygosaccharomyces pastoris by Alexandre Guilliermond who is French mycologist in 19201. After, similar strains were isolated from oak trees by Herman Phaff and given the name P. pastoris 30-40 years...
HPV’s Potential Role in Thyroid Cancer
Human Papillomavirus (HPV) is a DNA virus that infects various human epithelial cells. Although HPV is primarily associated with cervical cancer, there is increasing research on its potential involvement in other types of cancer. The role of HPV in cancer formation is...
Sensory Neurons: Orchestrating Lung Immune Harmony
The human body intricately responds to various stimuli, encompassing living tissue and an array of living and non-living factors, including bacteria, viruses, and toxic chemicals. Inflammation, a pivotal facet of the body's defense mechanism against injury or...