Proteomic Age Clock: A New Way to Understand Aging
Aging has a significant impact on chronic diseases and mortality rates. As people age, the incidence of these diseases increases; however, chronological age may not fully reflect individuals' biological aging processes. Omic data allow for a more accurate prediction...
Reappraisal and Shame Management: Comparing Autism and Typical Individuals
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition marked by repetitive behaviors, restricted interests, emotional dysregulation, and significant challenges in social interactions. The social impairments characteristic of ASD often lead to...
The Power of Genetic Silencing: CRISPRoff vs ZFcharm
Prion disease derives from the accumulation of the misfolded, toxic forms of the proteins called PrnP in the neurons, which might conclude with the death of neurons. Along with the fact that it is a fatal and rare degenerative disorder, there is no treatment yet. It...
Epithelial Exosomes: New Frontiers in Fibrosis Diagnosis
Fibrosis involves the abnormal accumulation of extracellular matrix proteins and disrupted tissue repair, resulting in permanent scar tissue due to injury. Exosomes, tiny vesicles containing signaling molecules like mRNAs and proteins, are secreted by epithelial cells...
Potential Threat: Bioterrorism
Deniz AkyüzA. , Elif DuymazE. Since the dawn of humanity, societies and nascent states have often found themselves in contention with neighboring states and primitive communities. In those early years, the most formidable and influential tools wielded as leverage were...
Beyond CRISPR: Bacterial Genome Editing with Reprogrammable RNA
The rearrangement and diversification of the genome have endowed numerous enzymes through evolution. The emergence of new genes and their functional diversification, immune development, virus dissemination, and mobile genetic elements (MGEs) occur during this process....
Glioblastoma: Tumor Segregation and Immune Suppression via snRNA-seq
In the realm of glioblastoma (GBM) treatment, a malignant brain tumor with direct outcomes, conventional single cell technologies (TME) have played a pivotal role in discerning various cell types. However, they fall short in providing the precise tissue-level details...
Evolutionary Secret: Hominoid Tail Loss
The tail loss in human evolution is considered one of the most remarkable anatomical changes in the evolution process. Tail loss has led to people becoming bipedal and the formation of anthropomorph monkeys, but the genetic mechanism that initiated tail loss evolution...
Data Science Predicts: Cu-Catalyzed C–N Coupling Reactions
In recent years, advances in high-throughput experimentation (HTE) along with machine learning (ML) algorithms have revolutionized the process of identifying successful reactions in synthetic chemistry. ML algorithms, when combined with HTE, enable efficient...
Dynamic and Selective Engrams: Their Relationship to Memory Consolidation
A mounting body of evidence indicates the pivotal involvement of neurons activated during experiences in both the establishment and retrieval of memories. These neurons, termed engram cells, represent a foundational element in the process of memory encoding and...